FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
CV Term Report
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General Information
Term fatty acyl-CoA hydrolase activity ID (Ontology) GO:0047617 (Gene Ontology)
Definition Catalysis of the reaction: a fatty acyl-CoA + H2O = a fatty acid + CoA + H+.
Also Known As "acyl-CoA thioesterase activity" ; "acyl-CoA thiolesterase activity"
Comment
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Annotations
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Data Class Field Records
Genes (FBgn)  GO_MOLECULAR_FUNCTION       7
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 Full annotation statements 
Relevant FlyBase reports
 Genes
 fatty acyl-CoA hydrolase activity (all annotations which use CV term, excluding "NOT" statements)       7
     enables | fatty acyl-CoA hydrolase activity       7
Spanning Tree (Parents/Children)
Only view relationship: 
thiolester hydrolase activity__
deacylase activity_____________|
                               acyl-CoA hydrolase activity
                                |__fatty acyl-CoA hydrolase activity  9 rec.
                                    |__long-chain fatty acyl-CoA hydrolase activity 1 rec.
                                    |__medium-chain fatty acyl-CoA hydrolase activity
                                    |__short-chain fatty acyl-CoA hydrolase activity 1 rec.
                                    |   |__3-hydroxyisobutyryl-CoA hydrolase activity 1 rec.
                                    |__very long-chain fatty acyl-CoA hydrolase activity
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Is a acyl-CoA hydrolase activity
Part of
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Synonyms
  • "acyl coenzyme A hydrolase activity" RELATED[ EC:3 ]
    "acyl coenzyme A thioesterase activity" RELATED[ EC:3 ]
    "acyl-CoA hydrolase activity" BROAD
    "acyl-CoA thioesterase activity" EXACT
    "acyl-CoA thioesterase I activity" NARROW
    "acyl-CoA thioesterase II activity" NARROW
    "acyl-CoA thiolesterase activity" EXACT
    "thioesterase B" RELATED[ EC:3 ]
    "thioesterase II" RELATED[ EC:3 ]
Secondary IDs
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EC:3.1.2.20
MetaCyc:ACYL-COA-HYDROLASE-RXN
Reactome:R-HSA-5690042 "Peroxisomal ACOT4,6,8 hydrolyse MCFA-CoA, LCFA-CoA"
Reactome:R-HSA-5690043 "Cytosolic ACOTs hydrolyse MCFA-CoA, LCFA-CoA"
Reactome:R-HSA-5690066 "ACOT2,9,THEM4,5 hydrolyse MCFA-CoA, LCFA-CoA"
RHEA:16781