FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term 3-oxo-5-alpha-steroid 4-dehydrogenase (NADP+) activity ID (Ontology) GO:0047751 (Gene Ontology)
Definition Catalysis of the reaction: 3-oxo-5alpha-steroid + NADP+ = a 3-oxo-delta(4)-steroid + H+ + NADPH.
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Genes (FBgn)GO_MOLECULAR_FUNCTION
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 3-oxo-5-alpha-steroid 4-dehydrogenase (NADP+) activity (all annotations which use CV term, excluding "NOT" statements)
     enables | 3-oxo-5-alpha-steroid 4-dehydrogenase (NADP+) activity
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oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor
 |__enone reductase activity_________________________________________
steroid dehydrogenase activity, acting on the CH-CH group of donors  |
 |__3-oxo-5-alpha-steroid 4-dehydrogenase activity___________________|
                                                                     3-oxo-5-alpha-steroid 4-dehydrogenase (NADP+) activity  1 rec.
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Is a 3-oxo-5-alpha-steroid 4-dehydrogenase activity
enone reductase activity
Part of
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Synonyms
  • "3-oxosteroid 5alpha-reductase activity" RELATED[ EC:1 ]
    "3-oxosteroid delta4-dehydrogenase" BROAD
    "cholestenone 5-alpha-reductase activity" NARROW
    "cholestenone 5a-reductase activity" NARROW
    "cholestenone 5alpha-reductase activity" NARROW[ EC:1 ]
    "progesterone 5-alpha-reductase activity" NARROW
    "steroid 5alpha-hydrogenase activity" BROAD
    "steroid 5alpha-reductase" BROAD
    "sterol 5-alpha reductase activity" BROAD
    "testosterone 5alpha-reductase" NARROW
    "testosterone delta4-hydrogenase activity" NARROW
Secondary IDs
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EC:1.3.1.22
KEGG_REACTION:R02610
MetaCyc:1.3.99.5-RXN
MetaCyc:CHOLESTENONE-5-ALPHA-REDUCTASE-RXN
MetaCyc:RXN-4229
MetaCyc:RXN-711
RHEA:21952
RHEA:24552
RHEA:50816
RHEA:50820
RHEA:54384
RHEA:54416
RHEA:69987
RHEA:69991
RHEA:84191
RHEA:84195