FB2026_03 , released September 17, 2026
FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term prostaglandin-E synthase activity ID (Ontology) GO:0050220 (Gene Ontology)
Definition Catalysis of the reaction: prostaglandin H(2) = prostaglandin E(2).[ EC:5 ]
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Data ClassFieldDirect annotations
Genes (FBgn)GO_MOLECULAR_FUNCTION
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 prostaglandin-E synthase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | prostaglandin-E synthase activity
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  isomerase activity
   |__intramolecular oxidoreductase activity
       |__prostaglandin-E synthase activity  5 rec.
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Is a intramolecular oxidoreductase activity
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Synonyms
  • "(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate E-isomerase activity" RELATED[ EC:5 ]
    "endoperoxide isomerase activity" RELATED[ EC:5 ]
    "PGE isomerase activity" RELATED[ EC:5 ]
    "PGE2 isomerase activity" RELATED[ EC:5 ]
    "PGH-PGE isomerase activity" RELATED[ EC:5 ]
    "prostaglandin endoperoxide E isomerase activity" RELATED[ EC:5 ]
    "prostaglandin endoperoxide E2 isomerase activity" RELATED[ EC:5 ]
    "prostaglandin H-E isomerase activity" RELATED[ EC:5 ]
    "prostaglandin R-prostaglandin E isomerase activity" RELATED[ EC:5 ]
    "Prostaglandin-H(2) E-isomerase activity" RELATED[ EC:5 ]
    "prostaglandin-H2 E-isomerase activity" RELATED[ EC:5 ]
Secondary IDs
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EC:5.3.99.3
KEGG_REACTION:R02265
MetaCyc:PROSTAGLANDIN-E-SYNTHASE-RXN
Reactome:R-HSA-2161660 "PGH2 is isomerised to PGE2 by PTGES"
Reactome:R-HSA-265295 "Prostaglandin E synthase isomerizes PGH2 to PGE2"
RHEA:12893