FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term trimethyllysine dioxygenase activity ID (Ontology) GO:0050353 (Gene Ontology)
Definition Catalysis of the reaction: 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysine + O2 = 3-hydroxy-N(6),N(6),N(6)-trimethyl-L-lysine + CO2 + succinate.[ EC:1 ]
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Genes (FBgn)GO_MOLECULAR_FUNCTION
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 trimethyllysine dioxygenase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | trimethyllysine dioxygenase activity
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oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen__
dioxygenase activity___________________________________________________________________________________|
                                                                                         2-oxoglutarate-dependent dioxygenase activity
                                                                                          |__trimethyllysine dioxygenase activity  1 rec.
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Is a 2-oxoglutarate-dependent dioxygenase activity
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Synonyms
  • "6-N,6-N,6-N-trimethyl-L-lysine,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating)" RELATED[ EC:1 ]
    "epsilon-trimethyllysine 2-oxoglutarate dioxygenase activity" RELATED[ EC:1 ]
    "N6,N6,N6-trimethyl-L-lysine,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating)" RELATED[ EC:1 ]
    "TML dioxygenase activity" RELATED[ EC:1 ]
    "TML hydroxylase activity" RELATED[ EC:1 ]
    "TML-alpha-ketoglutarate dioxygenase activity" RELATED[ EC:1 ]
    "TMLD activity" RELATED[ EC:1 ]
    "trimethyllysine alpha-ketoglutarate dioxygenase activity" RELATED[ EC:1 ]
    "trimethyllysine,2-oxoglutarate dioxygenase activity" RELATED[ EC:1 ]
Secondary IDs
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EC:1.14.11.8
KEGG_REACTION:R03451
MetaCyc:TRIMETHYLLYSINE-DIOXYGENASE-RXN
Reactome:R-HSA-71241 "TMLHE dimer dioxygenates TMLYS and 2OG to form HTMLYS and SUCCA"
RHEA:14181