FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
CV Term Report
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General Information
Term glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity ID (Ontology) GO:0050508 (Gene Ontology)
Definition Catalysis of the reaction: 3-O-{[(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNAc](n)-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-{alpha-D-GlcNAc-[(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNAc](n)-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L-seryl-[protein] + H+ + UDP.
Also Known As "glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-a-N-acetylglucosaminyltransferase activity"
Comment
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Annotations
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Data Class Field Records
Genes (FBgn)  GO_MOLECULAR_FUNCTION       2
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 Full annotation statements 
Relevant FlyBase reports
 Gene Groups Genes
 glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity (all annotations which use CV term, excluding "NOT" statements)       1      2
     enables | glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity       --       2
Spanning Tree (Parents/Children)
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UDP-glycosyltransferase activity__
hexosyltransferase activity_______|
                                  acetylglucosaminyltransferase activity
                                   |__glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity  3 rec.
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Is a acetylglucosaminyltransferase activity
Part of
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Synonyms
  • "alpha-N-acetylglucosaminyltransferase II activity" RELATED[ EC:2 ]
    "glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-a-N-acetylglucosaminyltransferase activity" EXACT
    "glucuronyl-N-acetylglucosaminylproteoglycan alpha-1,4-N-acetylglucosaminyltransferase activity" RELATED[ EC:2 ]
    "UDP-N-acetyl-D-glucosamine:beta-D-glucuronosyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity" RELATED[ EC:2 ]
Secondary IDs
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EC:2.4.1.224
MetaCyc:2.4.1.224-RXN
Reactome:R-HSA-2022851 "EXT1:EXT2 transfer GlcNAc to the heparan chain"
Reactome:R-HSA-2022919 "EXT1:EXT2 transfers GlcNAc to the terminal GlcA residue"
Reactome:R-HSA-3656254 "Defective EXT2 (in EXT1:EXT2) does not transfer GlcNAc to the heparan chain"
Reactome:R-HSA-3656261 "Defective EXT1 (in EXT1:EXT2) does not transfer GlcNAc to the heparan chain"
Reactome:R-HSA-9036283 "Defective EXT1 (in EXT1:EXT2) does not transfer GlcNAc to the terminal GlcA residue"
Reactome:R-HSA-9036290 "Defective EXT2 (in EXT1:EXT2) does not transfer GlcNAc to heparan"
RHEA:16213