FB2026_03 , released September 17, 2026
FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity ID (Ontology) GO:0050509 (Gene Ontology)
Definition Catalysis of the reaction: 3-O-{alpha-D-GlcNAc-[(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNAc](n)-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L-seryl-[protein] + UDP-alpha-D-glucuronate = 3-O-{[(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNAc](n+1)-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L-seryl-[protein] + H+ + UDP.
Also Known As "N-acetylglucosaminyl-proteoglycan 4-b-glucuronosyltransferase activity"
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Data ClassFieldDirect annotations
Genes (FBgn)GO_MOLECULAR_FUNCTION
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 N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity       --
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UDP-glycosyltransferase activity__
hexosyltransferase activity_______|
                                  glucuronosyltransferase activity
                                   |__N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity  3 rec.
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Is a glucuronosyltransferase activity
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Synonyms
  • "heparan glucuronyltransferase II activity" RELATED[ EC:2 ]
    "N-acetylglucosaminyl-proteoglycan 4-b-glucuronosyltransferase activity" EXACT
    "N-acetylglucosaminylproteoglycan beta-1,4-glucuronyltransferase activity" RELATED[ EC:2 ]
    "UDP-alpha-D-glucuronate:N-acetyl-alpha-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-proteoglycan 4-beta-glucuronosyltransferase activity" RELATED[ EC:2 ]
Secondary IDs
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EC:2.4.1.225
MetaCyc:2.4.1.225-RXN
Reactome:R-HSA-2022856 "EXT1:EXT2 transfers GlcA to heparan"
Reactome:R-HSA-2076392 "EXT1:EXT2 transfers GlcA to heparan"
Reactome:R-HSA-3656257 "Defective EXT1 (in EXT1:EXT2) does not transfer GlcA to heparan"
Reactome:R-HSA-3656267 "Defective EXT2 (in EXT1:EXT2) does not transfer GlcA to heparan"
Reactome:R-HSA-9036285 "Defective EXT1 (in EXT1:EXT2) does not transfer GlcA to heparan"
Reactome:R-HSA-9036289 "Defective EXT2 (in EXT1:EXT2) does not transfer GlcA to heparan"
RHEA:20908