FB2026_03 , released September 17, 2026
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General Information
Term Delta14-sterol reductase activity ID (Ontology) GO:0050613 (Gene Ontology)
Definition Catalysis of the reaction: NADP+ + 4,4-dimethyl-5-alpha-cholesta-8,24-dien-3-beta-ol = NADPH + H+ + 4,4-dimethyl-5-alpha-cholesta-8,14,24-trien-3-beta-ol.[ EC:1 ]
Also Known As"C-14 sterol reductase activity" ; "D14-sterol reductase activity" ; "sterol C-14 reductase activity"
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 NOT | enables | Delta14-sterol reductase activity
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  oxidoreductase activity, acting on the CH-CH group of donors
   |__oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor
       |__Delta14-sterol reductase activity
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Is a oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor
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Synonyms
  • "4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol:NADP+ delta14-oxidoreductase activity" RELATED[ EC:1 ]
    "C-14 sterol reductase activity" EXACT
    "D14-sterol reductase activity" EXACT
    "sterol C-14 reductase activity" EXACT
    "sterol C14-reductase activity" RELATED[ EC:1 ]
Secondary IDs
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EC:1.3.1.70
MetaCyc:RXN66-14
Reactome:R-HSA-194674 "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [LBR]"
Reactome:R-HSA-194698 "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [TM7SF2]"
Reactome:R-HSA-9946140 "TM7SF2 reduces 4,4-diMeCholesta-8,14-dien-3-ol to 4,4-diMe5-cholest-8-en-3-ol"
RHEA:18561