FB2026_03 , released September 17, 2026

CV Term Report

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General Information

Term

negative regulation of synaptic transmission

ID (Ontology)

GO:0050805 (Gene Ontology)

Definition

Any process that stops, prevents, or reduces the frequency, rate or extent of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse.

Also Known As

"down regulation of synaptic transmission" ; "down-regulation of synaptic transmission" ; "downregulation of synaptic transmission"

Comment

Links to External Ontologies

QuickGO data AmiGO data

Annotations

Records annotated with this term OR any of its CHILD TERMS

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Direct annotations: records annotated with this exact term (child terms are NOT included)

Data Class	Field	Direct annotations
Genes (FBgn)	GO_BIOLOGICAL_PROCESS

Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records

Full annotation statements	Relevant FlyBase reports
Full annotation statements	Genes
negative regulation of synaptic transmission (all annotations which use CV term, excluding "NOT" statements)
involved_in \| negative regulation of synaptic transmission

Spanning Tree (Parents/Children)

chemical synaptic transmission
 |__modulation of chemical synaptic transmission__
regulation of cell communication                  |
 |__negative regulation of cell communication_____|
regulation of signaling                           |
 |__negative regulation of signaling______________|
negative regulation of biological process         |
 |__negative regulation of signaling______________|
negative regulation of cellular process           |
 |__negative regulation of cell communication_____|
regulation of trans-synaptic signaling            |
 |__modulation of chemical synaptic transmission__|
                                                  negative regulation of synaptic transmission  18 rec.
                                                   |__long-term synaptic depression 1 rec.
                                                   |   |__regulation of long-term synaptic depression(+)
                                                   |__negative regulation of neuromuscular synaptic transmission 11 rec.
                                                   |__negative regulation of synaptic transmission, cholinergic 1 rec.
                                                   |   |__negative regulation of acetylcholine secretion, neurotransmission
                                                   |__negative regulation of synaptic transmission, dopaminergic
                                                   |__negative regulation of synaptic transmission, GABAergic 1 rec.
                                                   |__negative regulation of synaptic transmission, glutamatergic 1 rec.
                                                   |   |__negative regulation of glutamate secretion, neurotransmission 1 rec.
                                                   |__negative regulation of synaptic transmission, glycinergic
                                                       |__negative regulation of glycine secretion, neurotransmission

Spanning Tree View Settings
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Relationships
Is a	negative regulation of cell communication negative regulation of signaling modulation of chemical synaptic transmission
Part of
Synonyms & Secondary IDs
Synonyms
	"down regulation of synaptic transmission" EXACT "down-regulation of synaptic transmission" EXACT "downregulation of synaptic transmission" EXACT "inhibition of synaptic transmission" NARROW
Secondary IDs

External Crossreferences & Linkouts