FB2026_03 , released September 17, 2026

CV Term Report

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General Information

Term

G-quadruplex DNA binding

ID (Ontology)

GO:0051880 (Gene Ontology)

Definition

Binding to G-quadruplex DNA structures, in which groups of four guanines adopt a flat, cyclic Hoogsteen hydrogen-bonding arrangement known as a guanine tetrad. The stacking of guanine tetrads results in G-quadruplex DNA structures. G-quadruplex DNA can form under physiological conditions from some G-rich sequences, such as those found in telomeres, immunoglobulin switch regions, gene promoters, fragile X repeats, and the dimerization domain in the human immunodeficiency virus (HIV) genome.[ PubMed:16142245 PubMed:9512530 ]

Also Known As

"G quadruplex DNA binding" ; "G quartet DNA binding" ; "G-DNA binding" (for all, see Synonyms field below)

Comment

Links to External Ontologies

QuickGO data AmiGO data

Annotations

Records annotated with this term OR any of its CHILD TERMS

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Direct annotations: records annotated with this exact term (child terms are NOT included)

Data Class	Field	Direct annotations
Genes (FBgn)	GO_MOLECULAR_FUNCTION

Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records

Full annotation statements	Relevant FlyBase reports
Full annotation statements	Genes
G-quadruplex DNA binding (all annotations which use CV term, excluding "NOT" statements)
enables \| G-quadruplex DNA binding

Spanning Tree (Parents/Children)

  nucleic acid binding
   |__DNA binding
       |__G-quadruplex DNA binding  2 rec.
           |__telomeric G-quadruplex DNA binding

Spanning Tree View Settings
Parents/Children View Depth	Show hierarchy levels: for parents, for children
Relationships
Is a	DNA binding
Part of
Synonyms & Secondary IDs
Synonyms
	"G quadruplex DNA binding" EXACT "G quartet binding" BROAD "G quartet DNA binding" EXACT "G-DNA binding" EXACT "G-quartet binding" BROAD "G-quartet DNA binding" EXACT "quadruplex DNA binding" EXACT "tetraplex DNA binding" EXACT
Secondary IDs

External Crossreferences & Linkouts