FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term S-(hydroxymethyl)glutathione dehydrogenase [NAD(P)+] activity ID (Ontology) GO:0051903 (Gene Ontology)
Definition Catalysis of the reaction: S-(hydroxymethyl)glutathione + NAD(P)+ = S-formylglutathione + NAD(P)H + H+.[ EC:1 ]
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Genes (FBgn)GO_MOLECULAR_FUNCTION
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 S-(hydroxymethyl)glutathione dehydrogenase [NAD(P)+] activity (all annotations which use CV term, excluding "NOT" statements)
     enables | S-(hydroxymethyl)glutathione dehydrogenase [NAD(P)+] activity
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  oxidoreductase activity, acting on CH-OH group of donors
   |__oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
       |__S-(hydroxymethyl)glutathione dehydrogenase [NAD(P)+] activity  1 rec.
           |__S-(hydroxymethyl)glutathione dehydrogenase (NAD+) activity 1 rec.
           |__S-(hydroxymethyl)glutathione dehydrogenase (NADP+) activity 1 rec.
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Is a oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
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Synonyms
  • "ADH3 activity" NARROW[ EC:1 ]
    "chi-ADH activity" NARROW[ EC:1 ]
    "class III alcohol dehydrogenase activity" RELATED[ EC:1 ]
    "FDH activity" RELATED[ EC:1 ]
    "formic dehydrogenase activity" RELATED[ EC:1 ]
    "GD-FALDH activity" RELATED[ EC:1 ]
    "glutathione-dependent formaldehyde dehydrogenase activity" RELATED[ EC:1 ]
    "GS-FDH activity" RELATED[ EC:1 ]
    "NAD- and glutathione-dependent formaldehyde dehydrogenase activity" RELATED[ EC:1 ]
    "NAD-dependent formaldehyde dehydrogenase activity" RELATED[ EC:1 ]
    "NAD-linked formaldehyde dehydrogenase activity" RELATED[ EC:1 ]
    "S-(hydroxymethyl)glutathione:NAD+ oxidoreductase activity" RELATED[ EC:1 ]
Secondary IDs
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EC:1.1.1.284
KEGG_REACTION:R06983
KEGG_REACTION:R07140
MetaCyc:RXN-2962
Reactome:R-HSA-5692237 "ADH5 oxidises S-HMGSH to S-FGSH"
UM-BBD_reactionID:r1146