FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
CV Term Report
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General Information
Term (R)-2-hydroxyglutarate dehydrogenase activity ID (Ontology) GO:0051990 (Gene Ontology)
Definition Catalysis of the reaction: (R)-2-hydroxyglutarate + acceptor = 2-oxoglutarate + reduced acceptor.
Also Known As "D-2-hydroxyglutarate dehydrogenase activity"
Comment
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Annotations
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Data Class Field Records
Genes (FBgn)  GO_MOLECULAR_FUNCTION       1
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 Genes
 (R)-2-hydroxyglutarate dehydrogenase activity (all annotations which use CV term, excluding "NOT" statements)       1
     enables | (R)-2-hydroxyglutarate dehydrogenase activity       1
Spanning Tree (Parents/Children)
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  oxidoreductase activity
   |__oxidoreductase activity, acting on CH-OH group of donors
       |__(R)-2-hydroxyglutarate dehydrogenase activity  1 rec.
           |__(R)-2-hydroxyglutarate (NAD+) dehydrogenase activity
           |__(R)-2-hydroxyglutarate-pyruvate transhydrogenase activity
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Is a oxidoreductase activity, acting on CH-OH group of donors
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Synonyms
  • "D-2-hydroxyglutarate dehydrogenase activity" EXACT
Secondary IDs
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EC:1.1.99.39
MetaCyc:RXN-14932
Reactome:R-HSA-880007 "(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2"
Reactome:R-HSA-880053 "2-oxoglutarate + NADPH + H+ => (R)-2-hydroxyglutarate + NADP+ [mutant IDH1]"
RHEA:38295
RHEA:51192
RHEA:51612
RHEA:57168