FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
CV Term Report
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General Information
Term phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity ID (Ontology) GO:0052629 (Gene Ontology)
Definition Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 5-phosphate + phosphate + 2 H+.[ PubMed:19901554 ]
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Data Class Field Records
Genes (FBgn)  GO_MOLECULAR_FUNCTION       2
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 Genes
 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity (all annotations which use CV term, excluding "NOT" statements)       2
     enables | phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity       2
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  phosphatidylinositol bisphosphate phosphatase activity
   |__phosphatidylinositol-3,5-bisphosphate phosphatase activity
       |__phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity  2 rec.
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Is a phosphatidylinositol-3,5-bisphosphate phosphatase activity
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EC:3.1.3.95
MetaCyc:RXN-10958
Reactome:R-HSA-1676065 "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane"
Reactome:R-HSA-1676105 "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane"
Reactome:R-HSA-1676203 "PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane"
Reactome:R-HSA-6809320 "PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane"
Reactome:R-HSA-6809778 "PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1"
Reactome:R-HSA-6809944 "PI(3,5)P2 is dephosphorylated to PI5P by the MTMR2:SBF2 tetramer at the plasma membrane"
RHEA:39019