FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term all-trans-retinol dehydrogenase (NADP+) activity ID (Ontology) GO:0052650 (Gene Ontology)
Definition Catalysis of the reaction: all-trans-retinol + NADP+ = all-trans-retinal + NADPH + H+.
Also Known As"NADP-retinol dehydrogenase activity"
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Genes (FBgn)GO_MOLECULAR_FUNCTION
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 all-trans-retinol dehydrogenase (NADP+) activity (all annotations which use CV term, excluding "NOT" statements)
     enables | all-trans-retinol dehydrogenase (NADP+) activity       --
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  alcohol dehydrogenase [NAD(P)+] activity
   |__alcohol dehydrogenase (NADP+) activity
       |__all-trans-retinol dehydrogenase (NADP+) activity  10 rec.
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Is a alcohol dehydrogenase (NADP+) activity
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Synonyms
  • "all-trans retinal reductase activity" BROAD[ EC:1 ]
    "all-trans-retinol dehydrogenase activity" BROAD[ EC:1 ]
    "NADP(H)-dependent retinol dehydrogenase/reductase activity" RELATED[ EC:1 ]
    "NADP-retinol dehydrogenase activity" EXACT
    "retinol dehydrogenase [NADP+] activity" RELATED[ EC:1 ]
    "retinol dehydrogenase activity" BROAD
    "retinol:NADP+ oxidoreductase activity" RELATED[ EC:1 ]
Secondary IDs
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EC:1.1.1.300
KEGG_REACTION:R08379
MetaCyc:RXN-10841
Reactome:R-HSA-2464803 "RDH8 reduces atRAL to atROL"
Reactome:R-HSA-2464822 "RDH12 reduces atRAL to atROL"
Reactome:R-HSA-2465921 "11cRDH oxidises 11cROL to 11cRAL"
Reactome:R-HSA-2465940 "atRAL is reduced to atROL"
Reactome:R-HSA-2466861 "Defective RDH12 does not reduce atRAL to atROL"
Reactome:R-HSA-5419165 "RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL"
Reactome:R-HSA-5615668 "AKR1C3 reduces atRAL to atROL"
Reactome:R-HSA-5623643 "RDH13 reduces atRAL to atROL"
Reactome:R-HSA-74872 "RDH10,11 oxidise 11cROL to 11cRAL"
RHEA:25033