FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term spermine oxidase activity ID (Ontology) GO:0052901 (Gene Ontology)
Definition Catalysis of the reaction: H2O + O2 + spermine = 3-aminopropanal + H2O2 + spermidine. Weak activity with N(1)-acetylspermine. The Arabidopsis thaliana enzyme converts norspermine to norspermidine.[ EC:1 ]
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Data ClassFieldDirect annotations
Genes (FBgn)GO_MOLECULAR_FUNCTION
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 spermine oxidase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | spermine oxidase activity
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  oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor
   |__polyamine oxidase activity
       |__spermine oxidase activity  1 rec.
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Is a polyamine oxidase activity
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Synonyms
  • "spermine:oxygen oxidoreductase (spermidine-forming) activity" BROAD[ EC:1 ]
Secondary IDs
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EC:1.5.3.16
KEGG_REACTION:R09076
MetaCyc:RXN-9015
Reactome:R-HSA-141341 "SMOX-3 oxidises SPN to SPM"
RHEA:25804
RHEA:25816