FB2026_02 , released June 18, 2026

CV Term Report

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General Information

Term

tRNA (guanine(37)-N1)-methyltransferase activity

ID (Ontology)

GO:0052906 (Gene Ontology)

Definition

Catalysis of the reaction: S-adenosyl-L-methionine + guanine(37) in tRNA = N(1)-methylguanine(37) in tRNA + S-adenosyl-L-homocysteine.[ EC:2 ]

Also Known As

"tRNA (guanine(37)-N(1))-methyltransferase activity" ; "tRNA (guanosine(37)-N(1))-methyltransferase activity" ; "tRNA (guanosine(37)-N1-)-methyltransferase activity"

Comment

Links to External Ontologies

QuickGO data AmiGO data

Annotations

Records annotated with this term OR any of its CHILD TERMS

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Results list data from multiple species. Choose a record type above to open its HitList.

Direct annotations: records annotated with this exact term (child terms are NOT included)

Data Class	Field	Direct annotations
Genes (FBgn)	GO_MOLECULAR_FUNCTION

Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records

Full annotation statements	Relevant FlyBase reports
Full annotation statements	Genes
tRNA (guanine(37)-N1)-methyltransferase activity (all annotations which use CV term, excluding "NOT" statements)
enables \| tRNA (guanine(37)-N1)-methyltransferase activity

Spanning Tree (Parents/Children)

tRNA methyltransferase activity____________________________
S-adenosylmethionine-dependent methyltransferase activity__|
                                                           tRNA (guanine) methyltransferase activity
                                                            |__tRNA (guanine(37)-N1)-methyltransferase activity  1 rec.

Spanning Tree View Settings
Parents/Children View Depth	Show hierarchy levels: for parents, for children
Relationships
Is a	tRNA (guanine) methyltransferase activity
Part of
Synonyms & Secondary IDs
Synonyms
	"transfer RNA (m(1)G(37)) methyltransferase activity" RELATED[ EC:2 ] "tRNA (guanine(37)-N(1))-methyltransferase activity" EXACT "tRNA (guanosine(37)-N(1))-methyltransferase activity" EXACT "tRNA (guanosine(37)-N1-)-methyltransferase activity" EXACT "tRNA (m(1)G(37)) methyltransferase activity" RELATED[ EC:2 ] "tRNA-(N(1)G37) methyltransferase activity" RELATED[ EC:2 ]
Secondary IDs

External Crossreferences & Linkouts
	EC:2.1.1.228 MetaCyc:RXN-12458 Reactome:R-HSA-6782859 "TRMT5 methylates guanosine yielding 1-methylguanosine at nucleotide 37 of tRNA(Phe)" RHEA:36899