FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term Wnt signaling pathway, planar cell polarity pathway ID (Ontology) GO:0060071 (Gene Ontology)
Definition A type of non-canonical Wnt signaling pathway in which Wnt binding to its receptor on the surface of a target cell results in the activation small G proteins such as Rho, Rac, and Cdc42 which, in turn activate effectors, including C-Jun N-terminal kinase (JNK) and Rho kinase (Rok). The signaling ends with change in the transcription of target genes and/or reorganisation of the cytoskeleton.[ PubMed:11532397 PubMed:25349257 PubMed:28293032 PubMed:37804416 ]
Also Known As"PCP pathway" ; "planar cell polarity pathway" ; "Wnt receptor signaling pathway, planar cell polarity pathway" (for all, see Synonyms field below)
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Genes (FBgn)GO_BIOLOGICAL_PROCESS
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 Wnt signaling pathway, planar cell polarity pathway (all annotations which use CV term, excluding "NOT" statements)
     involved_in | Wnt signaling pathway, planar cell polarity pathway
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  Wnt signaling pathway
   |__non-canonical Wnt signaling pathway
       |__Wnt signaling pathway, planar cell polarity pathway  1 rec.
           |__regulation of Wnt signaling pathway, planar cell polarity pathway
               |__negative regulation of Wnt signaling pathway, planar cell polarity pathway
               |__positive regulation of Wnt signaling pathway, planar cell polarity pathway
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Is a non-canonical Wnt signaling pathway
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Synonyms
  • "non-canonical Wnt signaling pathway" RELATED
    "PCP pathway" EXACT
    "planar cell polarity pathway" EXACT
    "Wnt receptor signaling pathway, planar cell polarity pathway" EXACT
    "Wnt receptor signalling pathway, planar cell polarity pathway" EXACT
    "Wnt-activated signaling pathway, planar cell polarity pathway" EXACT
    "Wnt-JNK signaling pathway" RELATED
    "Wnt-PCP signaling pathway" RELATED
Secondary IDs
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Reactome:R-HSA-4086400 "PCP/CE pathway"