FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
CV Term Report
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General Information
Term K63-linked deubiquitinase activity ID (Ontology) GO:0061578 (Gene Ontology)
Definition Hydrolysis of a ubiquitin unit from a ubiquitinated protein linked via the Lys63 residue of ubiquitin.[ PubMed:18313383 ]
Also Known As "K63-specific deubiquitinase activity" ; "Lys63-specific deubiquitinase activity"
Comment
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Annotations
Records annotated with this term OR any of its CHILD TERMS
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Records annotated with this exact term (annotations to child terms are NOT included)
Data Class Field Records
Genes (FBgn)  GO_MOLECULAR_FUNCTION       7
show Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
 Full annotation statements 
Relevant FlyBase reports
 Genes
 K63-linked deubiquitinase activity (all annotations which use CV term, excluding "NOT" statements)       7
     enables | K63-linked deubiquitinase activity       7
Spanning Tree (Parents/Children)
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  ubiquitin-like protein peptidase activity
   |__deubiquitinase activity
       |__K63-linked deubiquitinase activity  7 rec.
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Is a deubiquitinase activity
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Synonyms
  • "K63-specific deubiquitinase activity" EXACT
    "Lys63-specific deubiquitinase activity" EXACT
Secondary IDs
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Reactome:R-HSA-5357845 "K63polyUb-RIPK1 is deubiquitinated"
Reactome:R-HSA-5690856 "TNFAIP3 (A20) deubiquitinates K63polyUb-RIPK1"
Reactome:R-HSA-5691411 "BRCA1-A complex deubiquitinates K63polyUb-histone H2A"
Reactome:R-HSA-5691431 "PSMD14 cleaves K63-linked ubiquitin"
Reactome:R-HSA-5691439 "BRISC complex deubiquitinates NLRP3"
Reactome:R-HSA-5696547 "STAMBPL1 is a deubiquitinase"
Reactome:R-HSA-688136 "TNFAIP3 (A20) deubiquitinates RIP2"
Reactome:R-HSA-741411 "CYLD deubiquitinates NEMO"
Reactome:R-HSA-8869506 "TNFAIP3 in OTUD7B:TNFAIP3:ZRANB1 deubiquitinates K63polyUb-TRAF6"
Reactome:R-HSA-936381 "OTUD5 deubiquitinates TRAF3"
Reactome:R-HSA-936390 "CYLD mediated deubiquitination of DDX58 (RIG-I)"
Reactome:R-HSA-9685219 "SARS-CoV-1 nsp3 deubiquinates K63-linked pUb oligo-TRAF6 (TLR7/8 signaling)"
Reactome:R-HSA-9711016 "SARS-CoV-1 nsp3 deubiquinates K63-linked pUb-STING"
Reactome:R-HSA-9750942 "USP14 deubiquitinates NLRC5"
Reactome:R-HSA-9817400 "CYLD hydrolyses K63polyUb on RIPK1 within the TNFR1 complex"