FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term SUMO ligase activity ID (Ontology) GO:0061665 (Gene Ontology)
Definition Catalysis of the transfer of SUMO to a substrate protein via the reaction X-SUMO + S = X + S-SUMO, where X is either an E2 or E3 enzyme, the X-SUMO linkage is a thioester bond, and the S-SUMO linkage is an isopeptide bond between the C-terminal amino acid of SUMO and the epsilon-amino group of lysine residues in the substrate.
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Data ClassFieldDirect annotations
Genes (FBgn)GO_MOLECULAR_FUNCTION
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 Genes
 SUMO ligase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | SUMO ligase activity
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ubiquitin-like protein transferase activity
 |__SUMO transferase activity_______________
 |__ubiquitin-like protein ligase activity__|
                                            SUMO ligase activity  7 rec.
                                             |__SUMO-ubiquitin ligase activity
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Is a SUMO transferase activity
ubiquitin-like protein ligase activity
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Synonyms
  • "E3" BROAD
Secondary IDs
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Reactome:R-HSA-9834809 "SUMOylation of PKR"
Reactome:R-HSA-9842868 "TRIM28 in TRIM28:KRAB-ZFP:retroelement chromatin autoSUMOylates with SUMO2"