FB2026_03 , released September 17, 2026
CV Term Report
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Term NAD+ nucleosidase activity, cyclic ADP-ribose generating ID (Ontology) GO:0061809 (Gene Ontology)
Definition Catalysis of the reaction: NAD+ + H2O = ADP-D-ribose + nicotinamide + H+, in a two step reaction: first an ADP-ribosyl cyclase reaction to synthesise cyclic ADP-ribose, followed by a cyclic ADP-ribose hydrolase reaction to generate (linear) ADP-ribose.[ EC:3 PubMed:11866528 ]
Also Known As"ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase"
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Genes (FBgn)GO_MOLECULAR_FUNCTION
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 NAD+ nucleosidase activity, cyclic ADP-ribose generating (all annotations which use CV term, excluding "NOT" statements)
     enables | NAD+ nucleosidase activity, cyclic ADP-ribose generating
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  hydrolase activity, acting on glycosyl bonds
   |__hydrolase activity, hydrolyzing N-glycosyl compounds
       |__NAD+ nucleosidase activity, cyclic ADP-ribose generating  1 rec.
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Is a hydrolase activity, hydrolyzing N-glycosyl compounds
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Synonyms
  • "ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase" EXACT
    "NAD hydrolase" NARROW
    "NAD(+) nucleosidase" NARROW
    "NADase" NARROW
    "nicotinamide adenine dinucleotide nucleosidase" NARROW
Secondary IDs
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EC:3.2.2.6
MetaCyc:NADNUCLEOSID-RXN
Reactome:R-HSA-8870346 "BST1 hydrolyzes NAD+ to yield NAM and ADP-ribose"
Reactome:R-HSA-8938076 "CD38 hydrolyses NAD+ to NAM and ADP-ribose"
Reactome:R-HSA-9637699 "CpnT hydrolyses NAD+"
RHEA:38611
RHEA:38615