FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term Met1-linked polyubiquitin deubiquitinase activity ID (Ontology) GO:0061815 (Gene Ontology)
Definition Catalysis of the hydrolysis of ubiquitin units from Met1-linked (or linear) polyubiquitin chains.[ PubMed:26503766 PubMed:27702987 ]
Also Known As"cysteine-type deubiquitinase activity, acting on linear ubiquitin" ; "linear ubiquitin specific deubiquitinase activity" ; "Met1 linkage specific DUB" (for all, see Synonyms field below)
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Data ClassFieldDirect annotations
Genes (FBgn)GO_MOLECULAR_FUNCTION
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 Genes
 Met1-linked polyubiquitin deubiquitinase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | Met1-linked polyubiquitin deubiquitinase activity
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cysteine-type peptidase activity__
deubiquitinase activity___________|
                                  cysteine-type deubiquitinase activity
                                   |__Met1-linked polyubiquitin deubiquitinase activity  1 rec.
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Is a cysteine-type deubiquitinase activity
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Synonyms
  • "cysteine-type deubiquitinase activity, acting on linear ubiquitin" EXACT
    "deubiquitinase, acting on linear ubiquitin" BROAD
    "linear ubiquitin specific deubiquitinase activity" EXACT
    "Met1 linkage specific DUB" EXACT
    "ubiquitinyl hydrolase activity, acting on linear ubiquitin" EXACT
Secondary IDs
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Reactome:R-HSA-9818975 "CYLD hydrolyses M1polyUb on RIPK1 within the TNFR1 complex"