FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term acyl-CoA (8-3)-desaturase activity ID (Ontology) GO:0062076 (Gene Ontology)
Definition Catalysis of the reaction: (8Z,11Z,14Z)-eicosatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H+ + O2 = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O. Can also use a substrate with 3 double bonds (a (8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA) and add a fourth double bond (a (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA).
Also Known As"acyl-CoA D5-desaturase activity" ; "acyl-CoA delta(5)-desaturase activity" ; "acyl-CoA delta5-desaturase activity"
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Genes (FBgn)GO_MOLECULAR_FUNCTION
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 acyl-CoA (8-3)-desaturase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | acyl-CoA (8-3)-desaturase activity
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  oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water
   |__acyl-CoA desaturase activity
       |__acyl-CoA (8-3)-desaturase activity  2 rec.
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Is a acyl-CoA desaturase activity
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Synonyms
  • "acyl-CoA D5-desaturase activity" EXACT
    "acyl-CoA delta(5)-desaturase activity" EXACT
    "acyl-CoA delta5-desaturase activity" EXACT
Secondary IDs
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EC:1.14.19.44
RHEA:46420
RHEA:46424