FB2026_03 , released September 17, 2026
CV Term Report
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Term ERK1 and ERK2 cascade ID (Ontology) GO:0070371 (Gene Ontology)
Definition A MAPK cascade containing at least the ERK1 or ERK2 MAP kinases. It starts with the activation of a MAP3K, and the consecutive activation of a MPK2K and of ERK1 or ERK2. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier. The ERK1/ERK2 cascade is activated by mitogens, growth factors, G protein-coupled receptors, and results in cellular responses such as cell proliferation, cell differentiation and development.[ PubMed:20811974 PubMed:23125017 PubMed:28903453 ]
Also Known As"ERK1 and ERK2 signaling pathway" ; "ERK1 and ERK2 signalling pathway" ; "ERK1/2 cascade" (for all, see Synonyms field below)
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Genes (FBgn)GO_BIOLOGICAL_PROCESS
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 ERK1 and ERK2 cascade (all annotations which use CV term, excluding "NOT" statements)
     involved_in | ERK1 and ERK2 cascade
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  intracellular signaling cassette
   |__MAPK cascade
       |__ERK1 and ERK2 cascade  49 rec.
           |__regulation of ERK1 and ERK2 cascade 47 rec.
               |__negative regulation of ERK1 and ERK2 cascade 23 rec.
               |__positive regulation of ERK1 and ERK2 cascade 24 rec.
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Synonyms
  • "ERK cascade" BROAD
    "ERK1 and ERK2 signaling pathway" EXACT
    "ERK1 and ERK2 signalling pathway" EXACT
    "ERK1 cascade" NARROW
    "ERK1/2 cascade" EXACT
    "ERK2 cascade" NARROW
    "extracellular signal-regulated kinase 1/2 (ERK1/2) cascade" EXACT[ PubMed:20811974 ]
    "extracellular signal-regulated kinase 1/2 cascade" EXACT[ PubMed:20811974 ]
    "MAPK1 cascade" NARROW
    "MAPK3 cascade" NARROW
Secondary IDs
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Reactome:R-HSA-112409 "RAF-independent MAPK1/3 activation"