FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
CV Term Report
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General Information
Term endoribonuclease activity, cleaving siRNA-paired mRNA ID (Ontology) GO:0070551 (Gene Ontology)
Definition Catalysis of the endonucleolytic cleavage of the mRNA in a double-stranded RNA molecule formed by the base pairing of an mRNA with an siRNA, yielding 5'-phosphomonoesters.[ PubMed:15105377 ]
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Data Class Field Records
Genes (FBgn)  GO_MOLECULAR_FUNCTION       1
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 Full annotation statements 
Relevant FlyBase reports
 Genes
 endoribonuclease activity, cleaving siRNA-paired mRNA (all annotations which use CV term, excluding "NOT" statements)       1
     enables | endoribonuclease activity, cleaving siRNA-paired mRNA       1
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RNA endonuclease activity__________________
hydrolase activity, acting on ester bonds__|
                                           RNA endonuclease activity producing 5'-phosphomonoesters, hydrolytic mechanism
                                            |__endoribonuclease activity, cleaving siRNA-paired mRNA  1 rec.
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Is a RNA endonuclease activity producing 5'-phosphomonoesters, hydrolytic mechanism
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Synonyms
  • "argonaute endoribonuclease activity" RELATED
Secondary IDs
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Reactome:R-HSA-9820842 "AGO2 :endosiRNA hydrolyzes maternal mRNA in the zygote"