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| Term | RISC-loading complex | ID (Ontology) | GO:0070578 (Gene Ontology) | |||||||||||
| Definition | A trimeric protein complex required for the formation of a mature RNA-induced silencing complex (RISC). In humans the complex is composed of the endonuclease Dicer (DICER1), TRBP (TARBP2) and the Argonaute protein Ago2 (EIF2C2/AGO2). Within the complex, Dicer and TRBP are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto Ago2. Ago2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from Dicer and TRBP. This complex has endoribonuclease activity.[ PubMed:18178619 PubMed:19820710 ] | |||||||||||||
| Also Known As | "microRNA loading complex" ; "miRLC" | |||||||||||||
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Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
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endonuclease complex |__endoribonuclease complex |__RISC-loading complex 12 rec. |
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| Is a | endoribonuclease complex | ||
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