FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term gamma-secretase complex ID (Ontology) GO:0070765 (Gene Ontology)
Definition A protein complex that has aspartic-type endopeptidase activity and contains a presenilin catalytic subunit (either PSEN1 or PSEN2), an APH1 subunit (multiple genes and splice variants exist), nicastrin (NCT), and presenilin enhancer (aka PEN-2 or Psenen), as the core complex. Variants of the complex with different subunit compositions differ in localization and specific substrates. Additionally, variants of the complex exist that contain a additional regulatory subunit as well as the four core subunits; known regulatory subunits include gamma-secretase-activating protein (aka gSAP), TMP1 (aka TMED10), and CD147 antigen (aka basigin). Gamma-secretase cleaves type I transmembrane protein substrates, including the cell surface receptor Notch and the amyloid-beta precursor protein.[ PubMed:15286082 PubMed:15890777 PubMed:17047368 PubMed:22122073 PubMed:25565961 PubMed:28320827 PubMed:32616437 ]
Also Known As"presenilin complex"
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Genes (FBgn)GO_CELLULAR_COMPONENT
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 gamma-secretase complex (all annotations which use CV term, excluding "NOT" statements)
     part_of | gamma-secretase complex       --
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plasma membrane
 |__plasma membrane protein complex__
protein-containing complex           |
 |__catalytic complex________________|
membrane protein complex             |
 |__plasma membrane protein complex__|
                                     gamma-secretase complex  5 rec.
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Is a plasma membrane protein complex
catalytic complex
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Synonyms
  • "CD147-gamma-secretase complex (APH-1a, PS-1, PEN-2, NCT variant)" NARROW
    "gamma-secretase complex (APH1A, PSEN1, PSENEN, NCSTN variant)" NARROW
    "gamma-secretase complex (APH1A, PSEN2, PSENEN, NCSTN)" NARROW
    "gamma-secretase complex (APH1B, PSEN1, PSENEN, NCSTN)" NARROW
    "gamma-secretase complex (APH1B, PSEN2, PSENEN, NCSTN)" NARROW
    "presenilin complex" EXACT
    "PS1 complex" NARROW
    "PS2 complex" NARROW
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