FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term peptidyl-lysine 5-dioxygenase activity ID (Ontology) GO:0070815 (Gene Ontology)
Definition Catalysis of the reaction: L-lysyl-[protein] + 2-oxoglutarate + O2 = (5S)-5-hydroxy-L-lysyl-[protein] + succinate + CO2.[ PubMed:19574390 ]
Also Known As"peptide-lysine 5-dioxygenase activity" ; "protein lysine hydroxylase activity"
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Genes (FBgn)GO_MOLECULAR_FUNCTION
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 peptidyl-lysine 5-dioxygenase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | peptidyl-lysine 5-dioxygenase activity
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catalytic activity
 |__catalytic activity, acting on a protein____________________________________________________________
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen  |
 |__2-oxoglutarate-dependent dioxygenase activity______________________________________________________|
dioxygenase activity                                                                                   |
 |__2-oxoglutarate-dependent dioxygenase activity______________________________________________________|
                                                                                         peptidyl-lysine 5-dioxygenase activity  1 rec.
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Is a 2-oxoglutarate-dependent dioxygenase activity
catalytic activity, acting on a protein
Part of
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Synonyms
  • "lysine hydroxylase activity" BROAD
    "lysine,2-oxoglutarate 5-dioxygenase activity" BROAD
    "lysine-2-oxoglutarate dioxygenase activity" BROAD
    "lysyl hydroxylase activity" BROAD
    "peptide-lysine 5-dioxygenase activity" EXACT
    "peptidyl-lysine, 2-oxoglutarate: oxygen oxidoreductase activity" RELATED[ EC:1 ]
    "peptidyllysine, 2-oxoglutarate:oxygen 5-oxidoreductase activity" RELATED[ EC:1 ]
    "protein lysine hydroxylase activity" EXACT
Secondary IDs
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Reactome:R-HSA-9630022 "JMJD6 dimer hydroxylates lysine residues of U2AF2"
RHEA:58360