FB2026_03 , released September 17, 2026
FB2026_03 , released September 17, 2026
CV Term Report
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Term core mediator complex ID (Ontology) GO:0070847 (Gene Ontology)
Definition A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The core mediator complex has a stimulatory effect on basal transcription, and contains most of the same subdomains as the larger form of mediator complex -- a head domain comprising proteins known in Saccharomyces as Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; and a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p -- but lacks the regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan core mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins.[ PubMed:11454195 PubMed:16168358 PubMed:17870225 ]
Also Known As "C mediator complex" ; "S mediator complex"
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Genes (FBgn)GO_CELLULAR_COMPONENT
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 core mediator complex (all annotations which use CV term, excluding "NOT" statements)
     part_of | core mediator complex
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transcription regulator complex_____
nuclear protein-containing complex__|
                                    RNA polymerase II transcription regulator complex
                                     |__core mediator complex  14 rec.
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Is a RNA polymerase II transcription regulator complex
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