FB2026_03 , released September 17, 2026

CV Term Report

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General Information

Term

microprocessor complex

ID (Ontology)

GO:0070877 (Gene Ontology)

Definition

A protein complex that binds to heme and to pri-miRNAs, and is required for the formation of a pre-microRNA (pre-miRNA), the initial step of microRNA (miRNA) biogenesis. The complex is composed of the double-stranded-RNA-specific RNase Drosha (also called RNASEN) and the RNA-binding protein DGCR8 (heme-free or heme-bound forms). Within the complex, DGCR8 function as a molecular anchor necessary for the recognition of pri-miRNA at dsRNA-ssRNA junction and directs RNASEN/Drosha to cleave the 3' and 5' strands of a stem-loop to release hairpin-shaped pre-miRNAs.[ PubMed:16963499 PubMed:17159994 ]

Comment

Links to External Ontologies

QuickGO data AmiGO data

Annotations

Records annotated with this term OR any of its CHILD TERMS

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Direct annotations: records annotated with this exact term (child terms are NOT included)

Data Class	Field	Direct annotations
Genes (FBgn)	GO_CELLULAR_COMPONENT

Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records

Full annotation statements	Relevant FlyBase reports
Full annotation statements	Genes
microprocessor complex (all annotations which use CV term, excluding "NOT" statements)
part_of \| microprocessor complex

Spanning Tree (Parents/Children)

nucleus
 |__nuclear protein-containing complex__
protein-containing complex              |
 |__nuclear protein-containing complex__|
endoribonuclease complex                |
 |__ribonuclease III complex____________|
                                        microprocessor complex  2 rec.

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Relationships
Is a	nuclear protein-containing complex ribonuclease III complex
Part of
Synonyms & Secondary IDs
Synonyms

Secondary IDs

External Crossreferences & Linkouts