FB2026_03 , released September 17, 2026
FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term RISC complex assembly ID (Ontology) GO:0070922 (Gene Ontology)
Definition The process in which a single-stranded small RNA is incorporated within the RNA-initiated silencing complex (RISC). The assembly includes the maturation of the small RNA, the stabilization of the complex by accessory proteins of the RISC complex, duplex separation and the release of the second strand, forming a base-pairing complement complex that mediates gene silencing by small RNA.[ PubMed:14512631 PubMed:14744438 PubMed:19239886 PubMed:22233755 PubMed:27184117 ]
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Genes (FBgn)GO_BIOLOGICAL_PROCESS
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 RISC complex assembly (all annotations which use CV term, excluding "NOT" statements)
     involved_in | RISC complex assembly       --
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negative regulation of gene expression
 |__regulatory ncRNA-mediated gene silencing__
ribonucleoprotein complex biogenesis          |
 |__protein-RNA complex assembly______________|
protein-containing complex assembly           |
 |__protein-RNA complex assembly______________|
protein-RNA complex organization              |
 |__protein-RNA complex assembly______________|
                                              RISC complex assembly  15 rec.
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Is a protein-RNA complex assembly
Part of regulatory ncRNA-mediated gene silencing
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Synonyms
  • "gene silencing by RNA, small RNA loading onto RISC" RELATED
    "miRISC assembly" BROAD
    "miRNA loading onto RISC" NARROW
    "RISC assembly" RELATED
    "siRNA loading onto RISC involved in gene silencing by small RNA" NARROW
    "siRNA loading onto RISC involved in RNA interference" NARROW
    "small RNA loading onto RISC" RELATED
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