FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term histone H3K27me2/H3K27me3 demethylase activity ID (Ontology) GO:0071558 (Gene Ontology)
Definition Catalysis of the removal of a methyl group from a tri- or a dimethyl-lysine residue at position 27 of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate.[ PubMed:20622853 ]
Also Known As"histone H3-tri/di-methyl-lysine-27 demethylase activity"
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Genes (FBgn)GO_MOLECULAR_FUNCTION
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 histone H3K27me2/H3K27me3 demethylase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | histone H3K27me2/H3K27me3 demethylase activity       --
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oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
 |__2-oxoglutarate-dependent dioxygenase activity__
histone demethylase activity                       |
 |__histone H3 demethylase activity________________|
dioxygenase activity                               |
 |__2-oxoglutarate-dependent dioxygenase activity__|
                                                   histone H3K27me2/H3K27me3 demethylase activity  2 rec.
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Is a 2-oxoglutarate-dependent dioxygenase activity
histone H3 demethylase activity
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Synonyms
  • "histone demethylase activity (H3-K27 specific)" BROAD
    "histone H3-tri/di-methyl-lysine-27 demethylase activity" EXACT
    "histone H3K27me2 demethylase activity" RELATED
    "histone H3K27me3 demethylase activity" RELATED
Secondary IDs
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EC:1.14.11.68
Reactome:R-HSA-3222593 "KDM6B demethylates H3K27me3 on p16INK4A promoter"
Reactome:R-HSA-5617431 "Retinoic acid activates HOXA1 chromatin"
Reactome:R-HSA-5617887 "HOXC4 chromatin is activated"
Reactome:R-HSA-9822914 "KDM6B (JMJD3) demethylates histone H3 trimethyllysine-27 (H3K27me3)"
Reactome:R-HSA-9822985 "KDM6A (UTX) demethylates histone H3 trimethyllysine-27 (H3K27me3)"
RHEA:60224