FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
CV Term Report
Help Close All Open All
General Information
Term histone H3K27me2/H3K27me3 demethylase activity ID (Ontology) GO:0071558 (Gene Ontology)
Definition Catalysis of the removal of a methyl group from a tri- or a dimethyl-lysine residue at position 27 of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate.[ PubMed:20622853 ]
Also Known As "histone H3-tri/di-methyl-lysine-27 demethylase activity"
Comment
Links to External Ontologies
  QuickGO data     AmiGO data
Annotations
Records annotated with this term OR any of its CHILD TERMS
    Results list data from multiple species. Click on a button above and use the 'Filter by species' options on the resulting HitList to retrieve species-specific data.
Records annotated with this exact term (annotations to child terms are NOT included)
Data Class Field Records
Genes (FBgn)  GO_MOLECULAR_FUNCTION       1
show Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
 Full annotation statements 
Relevant FlyBase reports
 Gene Groups Genes
 histone H3K27me2/H3K27me3 demethylase activity (all annotations which use CV term, excluding "NOT" statements)       1      1
     enables | histone H3K27me2/H3K27me3 demethylase activity       --       1
Spanning Tree (Parents/Children)
Only view relationship: 
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
 |__2-oxoglutarate-dependent dioxygenase activity__
histone demethylase activity                       |
 |__histone H3 demethylase activity________________|
dioxygenase activity                               |
 |__2-oxoglutarate-dependent dioxygenase activity__|
                                                   histone H3K27me2/H3K27me3 demethylase activity  2 rec.
Spanning Tree View Settings
Parents/Children
View Depth
Show hierarchy levels: for parents, for children
hide Relationships
Is a 2-oxoglutarate-dependent dioxygenase activity
histone H3 demethylase activity
Part of
hide Synonyms & Secondary IDs
Synonyms
  • "histone demethylase activity (H3-K27 specific)" BROAD
    "histone H3-tri/di-methyl-lysine-27 demethylase activity" EXACT
    "histone H3K27me2 demethylase activity" RELATED
    "histone H3K27me3 demethylase activity" RELATED
Secondary IDs
hide External Crossreferences & Linkouts
EC:1.14.11.68
Reactome:R-HSA-3222593 "KDM6B demethylates H3K27me3 on p16INK4A promoter"
Reactome:R-HSA-5617431 "Retinoic acid activates HOXA1 chromatin"
Reactome:R-HSA-5617887 "HOXC4 chromatin is activated"
Reactome:R-HSA-9822914 "KDM6B (JMJD3) demethylates histone H3 trimethyllysine-27 (H3K27me3)"
Reactome:R-HSA-9822985 "KDM6A (UTX) demethylates histone H3 trimethyllysine-27 (H3K27me3)"
RHEA:60224