FB2026_03 , released September 17, 2026

CV Term Report

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General Information

Term

nuclear protein quality control by the ubiquitin-proteasome system

ID (Ontology)

GO:0071630 (Gene Ontology)

Definition

A protein quality control pathway that results in the breakdown of misfolded, damaged or unassembled proteins via a mechanism in which the proteins are ubiquitinated, and then targeted to nuclear proteasomes for degradation.[ PubMed:20080635 PubMed:21211726 ]

Also Known As

"nucleus-associated proteasomal ubiquitin-dependent protein breakdown" ; "nucleus-associated proteasomal ubiquitin-dependent protein catabolism" ; "nucleus-associated proteasomal ubiquitin-dependent protein degradation" (for all, see Synonyms field below)

Comment

Links to External Ontologies

QuickGO data AmiGO data

Annotations

Records annotated with this term OR any of its CHILD TERMS

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Direct annotations: records annotated with this exact term (child terms are NOT included)

Data Class	Field	Direct annotations
Genes (FBgn)	GO_BIOLOGICAL_PROCESS

Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records

Full annotation statements	Relevant FlyBase reports
Full annotation statements	Genes
nuclear protein quality control by the ubiquitin-proteasome system (all annotations which use CV term, excluding "NOT" statements)
involved_in \| nuclear protein quality control by the ubiquitin-proteasome system

Spanning Tree (Parents/Children)

ubiquitin-dependent protein catabolic process
 |__proteasome-mediated ubiquitin-dependent protein catabolic process___________
proteasomal protein catabolic process                                           |
 |__proteasome-mediated ubiquitin-dependent protein catabolic process___________|
protein catabolic process                                                       |
 |__protein quality control for misfolded or incompletely synthesized proteins__|
cellular response to topologically incorrect protein                            |
 |__cellular response to misfolded protein______________________________________|
response to misfolded protein                                                   |
 |__cellular response to misfolded protein______________________________________|
                                                                                nuclear protein quality control by the ubiquitin-proteasome system  1 rec.
                                                                                 |__inner nuclear membrane-associated protein degradation pathway

Spanning Tree View Settings
Parents/Children View Depth	Show hierarchy levels: for parents, for children
Relationships
Is a	protein quality control for misfolded or incompletely synthesized proteins proteasome-mediated ubiquitin-dependent protein catabolic process
Part of	cellular response to misfolded protein
Synonyms & Secondary IDs
Synonyms
	"nucleus-associated proteasomal ubiquitin-dependent protein breakdown" EXACT "nucleus-associated proteasomal ubiquitin-dependent protein catabolism" EXACT "nucleus-associated proteasomal ubiquitin-dependent protein degradation" EXACT "ubiquitin-dependent catabolism of misfolded proteins by nucleus-associated proteasome" EXACT
Secondary IDs

External Crossreferences & Linkouts