FB2026_03 , released September 17, 2026

CV Term Report

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General Information

Term

LUBAC complex

ID (Ontology)

GO:0071797 (Gene Ontology)

Definition

A ubiquitin ligase complex that catalyzes linear head-to-tail polyubiquitin conjugation on its targets. In human the complex consists of RBCK1, RNF31 and SHARPIN, and has an MW of approximately 600 kDa, suggesting a heteromultimeric assembly of its subunits. LUBAC stands for Linear Ubiquitin Chain Assembly Complex.[ PubMed:17006537 PubMed:19136968 PubMed:21455180 ]

Comment

Links to External Ontologies

QuickGO data AmiGO data

Annotations

Records annotated with this term OR any of its CHILD TERMS

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Direct annotations: records annotated with this exact term (child terms are NOT included)

Data Class	Field	Direct annotations
Genes (FBgn)	GO_CELLULAR_COMPONENT

Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records

Full annotation statements	Relevant FlyBase reports
Full annotation statements	Genes
LUBAC complex (all annotations which use CV term, excluding "NOT" statements)
part_of \| LUBAC complex

Spanning Tree (Parents/Children)

intracellular protein-containing complex__
transferase complex_______________________|
                                          ubiquitin ligase complex
                                           |__LUBAC complex  1 rec.

Spanning Tree View Settings
Parents/Children View Depth	Show hierarchy levels: for parents, for children
Relationships
Is a	ubiquitin ligase complex
Part of
Synonyms & Secondary IDs
Synonyms

Secondary IDs

External Crossreferences & Linkouts