FB2026_03 , released September 17, 2026

CV Term Report

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General Information

Term

N-terminal protein N-methyltransferase activity

ID (Ontology)

GO:0071885 (Gene Ontology)

Definition

Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine (AdoMet) to the alpha-amino group of the N-terminal amino or imino acid residue of a protein substrate. For example, yeast Tae1p and mammalian family member METTL11A preferentially modify the N-terminal residue of substrates with the N-terminal sequence X-Pro-Lys, where X can be Pro, Ala, or Ser.[ PubMed:20481588 ]

Comment

Links to External Ontologies

QuickGO data AmiGO data

Annotations

Records annotated with this term OR any of its CHILD TERMS

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Direct annotations: records annotated with this exact term (child terms are NOT included)

Data Class	Field	Direct annotations
Genes (FBgn)	GO_MOLECULAR_FUNCTION

Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records

Full annotation statements	Relevant FlyBase reports
Full annotation statements	Genes
N-terminal protein N-methyltransferase activity (all annotations which use CV term, excluding "NOT" statements)
enables \| N-terminal protein N-methyltransferase activity

Spanning Tree (Parents/Children)

methyltransferase activity
 |__protein methyltransferase activity_________________________
 |__S-adenosylmethionine-dependent methyltransferase activity__|
catalytic activity, acting on a protein                        |
 |__protein methyltransferase activity_________________________|
                                                               N-terminal protein N-methyltransferase activity  1 rec.

Spanning Tree View Settings
Parents/Children View Depth	Show hierarchy levels: for parents, for children
Relationships
Is a	protein methyltransferase activity S-adenosylmethionine-dependent methyltransferase activity
Part of
Synonyms & Secondary IDs
Synonyms
	"X-Pro-Lys N-terminal methyltransferase" NARROW
Secondary IDs

External Crossreferences & Linkouts
	EC:2.1.1.244