FB2026_02 , released June 18, 2026

CV Term Report

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General Information

Term

14-3-3 protein binding

ID (Ontology)

GO:0071889 (Gene Ontology)

Definition

Binding to a 14-3-3 protein. A 14-3-3 protein is any of a large family of approximately 30kDa acidic proteins which exist primarily as homo- and heterodimers within all eukaryotic cells, and have been implicated in the modulation of distinct biological processes by binding to specific phosphorylated sites on diverse target proteins, thereby forcing conformational changes or influencing interactions between their targets and other molecules. Each 14-3-3 protein sequence can be roughly divided into three sections: a divergent amino terminus, the conserved core region and a divergent carboxy-terminus. The conserved middle core region of the 14-3-3s encodes an amphipathic groove that forms the main functional domain, a cradle for interacting with client proteins.[ PubMed:15167810 PubMed:19575580 ]

Comment

Links to External Ontologies

QuickGO data AmiGO data

Annotations

Records annotated with this term OR any of its CHILD TERMS

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Direct annotations: records annotated with this exact term (child terms are NOT included)

Data Class	Field	Direct annotations
Genes (FBgn)	GO_MOLECULAR_FUNCTION

Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records

Full annotation statements	Relevant FlyBase reports
Full annotation statements	Genes
14-3-3 protein binding (all annotations which use CV term, excluding "NOT" statements)
enables \| 14-3-3 protein binding

Spanning Tree (Parents/Children)

  binding
   |__protein binding
       |__14-3-3 protein binding  3 rec.

Spanning Tree View Settings
Parents/Children View Depth	Show hierarchy levels: for parents, for children
Relationships
Is a	protein binding
Part of
Synonyms & Secondary IDs
Synonyms

Secondary IDs

External Crossreferences & Linkouts