FB2026_03 , released September 17, 2026
FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term Ragulator complex ID (Ontology) GO:0071986 (Gene Ontology)
Definition A vacuolar membrane-anchored guanine nucleotide exchange factor (GEF) complex for the Rag GTPases (Gtr1-Gtr2 GTPase complex GO:1990131) in TORC1 signaling pathway. In human, Ragulator is comprised of the membrane anchor subunit LAMTOR1 (Meh1p in S. cerevisiae, Lam1 in S. pombe), a GEF subunit LAMTOR2 ( Slm4 in S. cerevisiae , Lam2 in S. pombe ) , LAMTOR3 (no S. cerevisiae ortholog identified, Lam3 in S. pombe) , LAMTOR4 (no S. cerevisiae ortholog identified, Lam4 in S. pombe), and LAMTOR5 (no S. cerevisiae or S. pombe ortholog identified).[ PubMed:15989961 PubMed:16732272 PubMed:19177150 PubMed:19748353 PubMed:20381137 PubMed:22980980 PubMed:29199950 ]
Also Known As "MAPKSP1/ROBLD3/C11orf59 complex" ; "Rag GEF"
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Data ClassFieldDirect annotations
Genes (FBgn)GO_CELLULAR_COMPONENT
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 Ragulator complex (all annotations which use CV term, excluding "NOT" statements)
     part_of | Ragulator complex       --
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vacuole
 |__vacuolar membrane__________________________
membrane                                       |
 |__membrane protein complex___________________|
protein-containing complex                     |
 |__membrane protein complex___________________|
bounding membrane of organelle                 |
 |__vacuolar membrane__________________________|
intracellular protein-containing complex       |
 |__guanyl-nucleotide exchange factor complex__|
                                               Ragulator complex  6 rec.
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Is a guanyl-nucleotide exchange factor complex
membrane protein complex
Part of vacuolar membrane
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Synonyms
  • "EGO complex" RELATED
    "EGO-GSE complex" RELATED
    "GSE complex" RELATED
    "GTPase-containing complex for Gap1p sorting in the endosome" RELATED
    "MAPKSP1/ROBLD3/C11orf59 complex" EXACT
    "Rag GEF" EXACT
Secondary IDs
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