FB2026_03 , released September 17, 2026

CV Term Report

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General Information

Term

fatty acid 2-hydroxylase activity

ID (Ontology)

GO:0080132 (Gene Ontology)

Definition

Catalysis of the hydroxylation of the C-2 position in a fatty acid. The 2-hydroxylation may occur on free fatty acids or within the fatty acyl chain of a sphingolipid.[ PubMed:36902339 ]

Also Known As

"fatty acid alpha-hydroxylase activity"

Comment

Links to External Ontologies

QuickGO data AmiGO data

Annotations

Records annotated with this term OR any of its CHILD TERMS

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Direct annotations: records annotated with this exact term (child terms are NOT included)

Data Class	Field	Direct annotations
Genes (FBgn)	GO_MOLECULAR_FUNCTION

Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records

Full annotation statements	Relevant FlyBase reports
Full annotation statements	Genes
fatty acid 2-hydroxylase activity (all annotations which use CV term, excluding "NOT" statements)
enables \| fatty acid 2-hydroxylase activity

Spanning Tree (Parents/Children)

monooxygenase activity_________________________________________________________________________________
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen__|
                                                                                         oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen
                                                                                          |__fatty acid 2-hydroxylase activity  1 rec.
                                                                                              |__4-hydroxysphinganine ceramide fatty acyl 2-hydroxylase activity 1 rec.
                                                                                              |__dihydroceramide fatty acyl 2-hydroxylase activity
                                                                                              |__free fatty acid 2-hydroxylase activity 1 rec.

Spanning Tree View Settings
Parents/Children View Depth	Show hierarchy levels: for parents, for children
Relationships
Is a	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen
Part of
Synonyms & Secondary IDs
Synonyms
	"fatty acid alpha-hydroxylase activity" EXACT
Secondary IDs

External Crossreferences & Linkouts
	Reactome:R-HSA-5693761 "FA2H hydroxylates 1,2-saturated fatty acids"