FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term cytosolic [4Fe-4S] assembly targeting complex ID (Ontology) GO:0097361 (Gene Ontology)
Definition A protein complex capable of condensing two 2Fe-2S clusters into one 4Fe-4S center in the cytoplasm and nucleus. In humans it consists of MMS19, CIAO1, CIAO2A/CIAO2B, CIAO3. MMS19, CIAO1 and CIAO2A/CIAO2B form a tight 'core' complex, whereas CIAO3 is an 'external' component of this complex.[ PubMed:23585563 PubMed:23891004 PubMed:34660592 ]
Also Known As"CIA targeting complex"
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Genes (FBgn)GO_CELLULAR_COMPONENT
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 cytosolic [4Fe-4S] assembly targeting complex (all annotations which use CV term, excluding "NOT" statements)
     part_of | cytosolic [4Fe-4S] assembly targeting complex       --
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cytoplasm
 |__iron-sulfur cluster assembly complex______
protein-containing complex                    |
 |__intracellular protein-containing complex__|
 |__iron-sulfur cluster assembly complex______|
                                              cytosolic [4Fe-4S] assembly targeting complex  5 rec.
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Is a intracellular protein-containing complex
iron-sulfur cluster assembly complex
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Synonyms
  • "CIA complex" BROAD
    "CIA targeting complex" EXACT[ PubMed:34660592 ]
    "cytosolic iron-sulfur protein assembly complex" RELATED
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