FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term synaptic vesicle lumen acidification ID (Ontology) GO:0097401 (Gene Ontology)
Definition The acidification of the synaptic vesicle lumen via transport of protons into the vesicle. The resulting electrochemical gradient powers neurotransmitter loading.[ PubMed:21172605 PubMed:22875945 ]
Also Known As"synaptic vesicle lumen pH reduction" ; "synaptic vesicle proton loading"
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Genes (FBgn)GO_BIOLOGICAL_PROCESS
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 synaptic vesicle lumen acidification (all annotations which use CV term, excluding "NOT" statements)
     involved_in | synaptic vesicle lumen acidification
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vesicle organization
 |__synaptic vesicle maturation____________
cellular homeostasis                       |
 |__neuron cellular homeostasis____________|
developmental maturation                   |
 |__synaptic vesicle maturation____________|
establishment of localization              |
 |__establishment of localization in cell__|
cellular localization                      |
 |__establishment of localization in cell__|
establishment of localization in cell      |
 |__synaptic vesicle cycle_________________|
monoatomic cation transmembrane transport  |
 |__proton transmembrane transport_________|
vesicle-mediated transport in synapse      |
 |__synaptic vesicle cycle_________________|
                                           synaptic vesicle lumen acidification  2 rec.
                                            |__regulation of synaptic vesicle lumen acidification
                                                |__negative regulation of synaptic vesicle lumen acidification
                                                |__positive regulation of synaptic vesicle lumen acidification
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Is a establishment of localization in cell
neuron cellular homeostasis
proton transmembrane transport
Part of synaptic vesicle maturation
synaptic vesicle cycle
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Synonyms
  • "synaptic vesicle lumen pH reduction" EXACT
    "synaptic vesicle proton loading" EXACT syngo_official_label
Secondary IDs
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