FB2026_02 , released June 18, 2026

CV Term Report

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General Information

Term

ubiquitin-dependent glycoprotein ERAD pathway

ID (Ontology)

GO:0097466 (Gene Ontology)

Definition

An ERAD pathway whereby endoplasmic reticulum (ER)-resident glycoproteins are targeted for degradation. Includes differential processing of the glycoprotein sugar chains, retrotranslocation to the cytosol and degradation by the ubiquitin-proteasome pathway. A glycoprotein is a compound in which a carbohydrate component is covalently bound to a protein component.[ PubMed:16079177 ]

Also Known As

"ER-associated glycoprotein degradation" ; "glycoprotein ERAD" ; "gpERAD"

Comment

Links to External Ontologies

QuickGO data AmiGO data

Annotations

Records annotated with this term OR any of its CHILD TERMS

Choose a record type to view annotations for this term and its child terms. Direct annotations and full annotation statements below also provide HitList buttons.

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Direct annotations: records annotated with this exact term (child terms are NOT included)

Data Class	Field	Direct annotations
Genes (FBgn)	GO_BIOLOGICAL_PROCESS

Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records

Full annotation statements	Relevant FlyBase reports
Full annotation statements	Gene Groups	Genes
ubiquitin-dependent glycoprotein ERAD pathway (all annotations which use CV term, excluding "NOT" statements)
involved_in \| ubiquitin-dependent glycoprotein ERAD pathway	--

Spanning Tree (Parents/Children)

glycoprotein metabolic process
 |__glycoprotein catabolic process_________
proteasomal protein catabolic process      |
 |__ERAD pathway___________________________|
protein catabolic process                  |
 |__glycoprotein catabolic process_________|
response to endoplasmic reticulum stress   |
 |__ERAD pathway___________________________|
response to chemical                       |
 |__ERAD pathway___________________________|
carbohydrate derivative catabolic process  |
 |__glycoprotein catabolic process_________|
response to oxygen-containing compound     |
 |__response to glycoprotein_______________|
                                           ubiquitin-dependent glycoprotein ERAD pathway  3 rec.
                                            |__mannose trimming involved in glycoprotein ERAD pathway

Spanning Tree View Settings
Parents/Children View Depth	Show hierarchy levels: for parents, for children
Relationships
Is a	glycoprotein catabolic process ERAD pathway response to glycoprotein
Part of
Synonyms & Secondary IDs
Synonyms
	"ER-associated glycoprotein degradation" EXACT "glycoprotein ERAD" EXACT "gpERAD" EXACT[ PubMed:25092655 ] "misfolded or incompletely synthesized glycoprotein catabolic process" BROAD
Secondary IDs

External Crossreferences & Linkouts