FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term ligand-gated calcium channel activity ID (Ontology) GO:0099604 (Gene Ontology)
Definition Enables the transmembrane transfer of a calcium ions by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts.
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Data ClassFieldDirect annotations
Genes (FBgn)GO_MOLECULAR_FUNCTION
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 ligand-gated calcium channel activity (all annotations which use CV term, excluding "NOT" statements)
     enables | ligand-gated calcium channel activity
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monoatomic cation channel activity
 |__calcium channel activity_________________________
 |__ligand-gated monoatomic cation channel activity__|
calcium ion transmembrane transporter activity       |
 |__calcium channel activity_________________________|
ligand-gated monoatomic ion channel activity         |
 |__ligand-gated monoatomic cation channel activity__|
                                                     ligand-gated calcium channel activity  19 rec.
                                                      |__glutamate-gated calcium ion channel activity 7 rec.
                                                      |__intracellularly gated calcium channel activity 7 rec.
                                                      |   |__cADPR-sensitive calcium-release channel activity
                                                      |   |__calcium-induced calcium release activity(+) 1 rec.
                                                      |   |__inositol 1,4,5-trisphosphate-gated calcium channel activity(+) 1 rec.
                                                      |   |__intracellularly ATP-gated calcium channel activity
                                                      |   |__NAADP-sensitive calcium-release channel activity 2 rec.
                                                      |__pH-gated calcium channel activity 1 rec.
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Is a calcium channel activity
ligand-gated monoatomic cation channel activity
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Reactome:R-HSA-1168376 "STIM1 oligomerizes"
Reactome:R-HSA-169680 "IP3 binds to the IP3 receptor, opening the endoplasmic reticulum Ca2+ channel"
Reactome:R-HSA-169683 "IP3R:I(1,4,5)P3 tetramer transports Ca2+ from ER lumen to cytosol"
Reactome:R-HSA-4420052 "Decreasing cGMP concentration promotes intracellular Ca2+ release in response to WNT"