FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
CV Term Report
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General Information
Term very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity ID (Ontology) GO:0102158 (Gene Ontology)
Definition Catalysis of the reaction: a very-long-chain (3R)-3-hydroxyacyl-CoA = H2O + a very-long-chain (2E)-enoyl-CoA. This reaction is the third (dehydration) step of the four-step fatty acid elongation cycle in the endoplasmic reticulum that extends fatty acids of C-16 or longer with an additional 2-C unit.[ PubMed:16564093 PubMed:19763486 ]
Also Known As "very-long-chain 3-hydroxyacyl-CoA dehydratase activity"
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Data Class Field Records
Genes (FBgn)  GO_MOLECULAR_FUNCTION       2
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Relevant FlyBase reports
 Genes
 very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity (all annotations which use CV term, excluding "NOT" statements)       2
     enables | very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity       2
Spanning Tree (Parents/Children)
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  3-hydroxyacyl-CoA dehydratase activity
   |__(2E)-enoyl-CoA hydratase activity
       |__very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity  2 rec.
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Is a (2E)-enoyl-CoA hydratase activity
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Synonyms
  • "very-long-chain 3-hydroxyacyl-CoA dehydratase activity" EXACT
Secondary IDs
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EC:4.2.1.134
MetaCyc:RXN-11750
RHEA:39199
RHEA:39211
RHEA:39223
RHEA:39235
RHEA:39271
RHEA:45812
RHEA:79187
RHEA:83119