FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term carboxylesterase activity ID (Ontology) GO:0106435 (Gene Ontology)
Definition Catalysis of the reaction: a carboxylic ester + H2O = a carboxylate + an alcohol + H+.
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Data ClassFieldDirect annotations
Genes (FBgn)GO_MOLECULAR_FUNCTION
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 carboxylesterase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | carboxylesterase activity       --
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  hydrolase activity, acting on ester bonds
   |__carboxylic ester hydrolase activity
       |__carboxylesterase activity  26 rec.
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Is a carboxylic ester hydrolase activity
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Synonyms
  • "ali-esterase activity" RELATED[ EC:3 ]
    "alpha-carboxylesterase activity" NARROW
    "B-esterase activity" NARROW[ EC:3 ]
    "cocaine esterase" NARROW[ EC:3 ]
    "nonspecific carboxylesterase activity" RELATED
    "procaine esterase" NARROW [] {comment="EC:3.1.1.1"}
    "serine esterase activity" NARROW
    "triacetin esterase" NARROW
    "vitamin A esterase" NARROW
Secondary IDs
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EC:3.1.1.1
MetaCyc:CARBOXYLESTERASE-RXN
Reactome:R-HSA-9619024 "CES1 trimer hydrolyses ACEI pro-drugs to ACEIs"
Reactome:R-HSA-9727567 "CES1 hydrolyses sacubitril to sacubitrilat"
Reactome:R-HSA-9749647 "CES2 hydrolyzes ASA-"
RHEA:21164
RHEA:31779
RHEA:38555
RHEA:47348
RHEA:47352
RHEA:47356
RHEA:47360
RHEA:47364
RHEA:47388
RHEA:47392
RHEA:50136
RHEA:50144
RHEA:50148
RHEA:59388
RHEA:63052