FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
CV Term Report
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General Information
Term cholesterol transfer activity ID (Ontology) GO:0120020 (Gene Ontology)
Definition Removes cholesterol from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle.[ PubMed:20823909 PubMed:24220498 PubMed:25797198 ]
Also Known As "cholesterol carrier activity"
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Annotations
Records annotated with this term OR any of its CHILD TERMS
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Records annotated with this exact term (annotations to child terms are NOT included)
Data Class Field Records
Genes (FBgn)  GO_MOLECULAR_FUNCTION       4
show Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
 Full annotation statements 
Relevant FlyBase reports
 Genes
 cholesterol transfer activity (all annotations which use CV term, excluding "NOT" statements)       4
     contributes_to | cholesterol transfer activity       1
     enables | cholesterol transfer activity       3
Spanning Tree (Parents/Children)
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  lipid transfer activity
   |__sterol transfer activity
       |__cholesterol transfer activity  4 rec.
           |__phosphatidylinositol-4-phosphate-cholesterol exchange activity
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Is a sterol transfer activity
Part of
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Synonyms
  • "cholesterol carrier activity" EXACT
    "cholesterol transporter activity" BROAD
    "intermembrane cholesterol transfer activity" NARROW
Secondary IDs
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Reactome:R-HSA-1454928 "ABCG4 may mediate cholesterol efflux"
Reactome:R-HSA-216723 "4xPALM-C-p-2S-ABCA1 tetramer transports CHOL from transport vesicle membrane to plasma membrane"
Reactome:R-HSA-265443 "NPC1L1-mediated cholesterol uptake"
Reactome:R-HSA-265545 "NPC1L1-mediated phytosterol uptake"
Reactome:R-HSA-266082 "ABCG1-mediated transport of intracellular cholesterol to the cell surface"
Reactome:R-HSA-5682111 "Defective ABCA1 does not transport CHOL from transport vesicle membrane to plasma membrane"
Reactome:R-HSA-8951850 "TSPO:BZRAP1 transports CHOL from outer mitochondrial membrane to inner mitochondrial membrane"