FB2026_03 , released September 17, 2026
CV Term Report
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Term 2-(3-amino-3-carboxypropyl)histidine synthase complex ID (Ontology) GO:0120513 (Gene Ontology)
Definition A protein complex capable of catalysing the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L-methionine (SAM) to the histidine residue of translation elongation factor 2 (EF2), which is the first step in the biosynthesis of diphthamide. The complex is a Dph2 homodimer in archaea and a Dph1-Dph2 heterodimer in eukaryotes.[ PubMed:24422557 PubMed:31463593 ]
Also Known As"Dph1-Dph2 complex"
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Genes (FBgn)GO_CELLULAR_COMPONENT
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 2-(3-amino-3-carboxypropyl)histidine synthase complex (all annotations which use CV term, excluding "NOT" statements)
     part_of | 2-(3-amino-3-carboxypropyl)histidine synthase complex       --
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  catalytic complex
   |__transferase complex
       |__2-(3-amino-3-carboxypropyl)histidine synthase complex  3 rec.
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Is a transferase complex
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  • "Dph1-Dph2 complex" EXACT
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