FB2026_02 , released June 18, 2026

CV Term Report

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General Information

Term

heme A synthase activity

ID (Ontology)

GO:0120547 (Gene Ontology)

Definition

Catalysis of the reaction: Fe(II)-heme o + 2 acceptor + H2O = Fe(II)-heme a + 2 acceptor-H2. The conversion of heme o to heme a occcurs by two successive hydroxylations of the methyl group at C8 using water as the oxygen source. The first hydroxylation forms heme i, the second hydroxylation results in an unstable dihydroxymethyl group, which spontaneously dehydrates, resulting in the formyl group of heme A.[ PubMed:30397130 ]

Comment

Links to External Ontologies

QuickGO data AmiGO data

Annotations

Records annotated with this term OR any of its CHILD TERMS

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Direct annotations: records annotated with this exact term (child terms are NOT included)

Data Class	Field	Direct annotations
Genes (FBgn)	GO_MOLECULAR_FUNCTION

Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records

Full annotation statements	Relevant FlyBase reports
Full annotation statements	Genes
heme A synthase activity (all annotations which use CV term, excluding "NOT" statements)
enables \| heme A synthase activity

Spanning Tree (Parents/Children)

  oxidoreductase activity
   |__oxidoreductase activity, acting on CH or CH2 groups
       |__heme A synthase activity  1 rec.

Spanning Tree View Settings
Parents/Children View Depth	Show hierarchy levels: for parents, for children
Relationships
Is a	oxidoreductase activity, acting on CH or CH2 groups
Part of
Synonyms & Secondary IDs
Synonyms

Secondary IDs

External Crossreferences & Linkouts
	EC:1.17.99.9 MetaCyc:RXN-18399 Reactome:R-HSA-2995334 "COX15 transforms heme O to heme A" RHEA:63388