FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term methyltransferase cap2 activity ID (Ontology) GO:0120550 (Gene Ontology)
Definition Catalysis of the reaction: a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleoside)-(ribonucleotide) in mRNA or snRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleoside)-(2'-O-methyl-ribonucleotide) in mRNA or snRNA + S-adenosyl-L-homocysteine + H+. This activity catalyzes the methylation of the ribose on the second transcribed nucleotide of mRNAs and snRNAs.[ EC:2 ]
Also Known As"cap2-MTase activity"
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Genes (FBgn)GO_MOLECULAR_FUNCTION
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 methyltransferase cap2 activity (all annotations which use CV term, excluding "NOT" statements)
     enables | methyltransferase cap2 activity
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methyltransferase activity
 |__O-methyltransferase activity____
 |__RNA methyltransferase activity__|
catalytic activity, acting on RNA   |
 |__RNA methyltransferase activity__|
                                    methyltransferase cap2 activity  1 rec.
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Is a O-methyltransferase activity
RNA methyltransferase activity
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Synonyms
  • "cap2-MTase activity" EXACT[ EC:2 ]
    "mRNA (nucleoside-2'-O-)-methyltransferase activity" RELATED[ EC:2 ]
Secondary IDs
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EC:2.1.1.296
MetaCyc:RXN-14928
RHEA:53044
RHEA:67024