FB2026_03 , released September 17, 2026
FB2026_03 , released September 17, 2026
CV Term Report
Help Close All Open All
General Information
Term branched-chain alpha-keto acid decarboxylation to branched-chain acyl-CoA ID (Ontology) GO:0120552 (Gene Ontology)
Definition The chemical reactions and pathways resulting in the formation of a branched-chain acyl-CoA by the oxidative decarboxylation of a branched-chain alpha-keto acid derived from L-leucine, L-isoleucine or L-valine. This pathway comprises a series of three reactions carried out by a multisubunit complex called the 'branched-chain alpha-keto acid dehydrogenase complex', even though branched-chain alpha-keto acid dehydrogenase activity describes only one of those reactions. The combination of the three reactions can be summarized as: 3-methyl-2-oxobutanoate + coenzyme A + NAD+ -> branched-chain acyl-CoA + CO2 + NADH. Specific substrates include 3-methyl-2-oxobutanoate (a transamination product of L-valine), (S)-3-methyl-2-oxopentanoate (a transamination product of L-isoleucine) and 4-methyl-2-oxopentanoate (a transamination product of L-leucine), which generate the products 2-methylpropanoyl-CoA, 2-methylbutanoyl-CoA and 3-methylbutanoyl-CoA, respectively.
Also Known As "branched-chain 2-oxo acid dehydrogenase system" ; "branched-chain alpha-keto acid dehydrogenase system"
Comment
Links to External Ontologies
  QuickGO data     AmiGO data
Annotations
Records annotated with this term OR any of its CHILD TERMS

Choose a record type to view annotations for this term and its child terms. Direct annotations and full annotation statements below also provide HitList buttons.

    • Results list data from multiple species. Choose a record type above to open its HitList.
Direct annotations: records annotated with this exact term (child terms are NOT included)
Data ClassFieldDirect annotations
Genes (FBgn)GO_BIOLOGICAL_PROCESS
show Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
 Full annotation statements 
Relevant FlyBase reports
 Gene Groups Genes
 branched-chain alpha-keto acid decarboxylation to branched-chain acyl-CoA (all annotations which use CV term, excluding "NOT" statements)
     involved_in | branched-chain alpha-keto acid decarboxylation to branched-chain acyl-CoA       --
Spanning Tree (Parents/Children)
Only view relationship:
Vocabulary search 
acyl-CoA metabolic process
 |__fatty-acyl-CoA metabolic process_____________
amino acid catabolic process                     |
 |__branched-chain amino acid catabolic process__|
branched-chain amino acid metabolic process      |
 |__branched-chain amino acid catabolic process__|
oxoacid metabolic process                        |
 |__carboxylic acid metabolic process____________|
carboxylic acid catabolic process                |
 |__branched-chain amino acid catabolic process__|
fatty acid derivative metabolic process          |
 |__fatty-acyl-CoA metabolic process_____________|
                                                 branched-chain alpha-keto acid decarboxylation to branched-chain acyl-CoA  5 rec.
Spanning Tree View Settings
Parents/Children
View Depth
Show hierarchy levels: for parents, for children
hide Relationships
Is a carboxylic acid metabolic process
fatty-acyl-CoA metabolic process
Part of branched-chain amino acid catabolic process
hide Synonyms & Secondary IDs
Synonyms
  • "branched-chain 2-oxo acid dehydrogenase system" EXACT
    "branched-chain alpha-keto acid dehydrogenase system" EXACT
Secondary IDs
hide External Crossreferences & Linkouts
MetaCyc:PWY-5046