FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
CV Term Report
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General Information
Term class I DNA-(apurinic or apyrimidinic site) endonuclease activity ID (Ontology) GO:0140078 (Gene Ontology)
Definition Catalysis of the cleavage of an AP site 3' of the baseless site by a beta-lyase mechanism, leaving an unsaturated aldehyde, termed a 3'-(4-hydroxy-5-phospho-2-pentenal) residue, and a 5'-phosphate.[ PubMed:1698278 ]
Also Known As "AP site-DNA 5'-phosphomonoester-lyase activity" ; "class I DNA-(apurinic or apyrimidinic site) lyase activity" ; "DNA-(apurinic or apyrimidinic site) 5'-phosphomonoester-lyase activity" (for all, see Synonyms field below)
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Genes (FBgn)GO_MOLECULAR_FUNCTION
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 class I DNA-(apurinic or apyrimidinic site) endonuclease activity (all annotations which use CV term, excluding "NOT" statements)
     enables | class I DNA-(apurinic or apyrimidinic site) endonuclease activity       --
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DNA endonuclease activity
 |__DNA-(apurinic or apyrimidinic site) endonuclease activity__
lyase activity                                                 |
 |__carbon-oxygen lyase activity_______________________________|
                                                               class I DNA-(apurinic or apyrimidinic site) endonuclease activity  6 rec.
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Is a DNA-(apurinic or apyrimidinic site) endonuclease activity
carbon-oxygen lyase activity
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Synonyms
  • "AP endonuclease class I activity" RELATED
    "AP lyase activity" RELATED
    "AP site-DNA 5'-phosphomonoester-lyase activity" EXACT
    "class I AP endonuclease activity" RELATED
    "class I DNA-(apurinic or apyrimidinic site) lyase activity" EXACT
    "DNA-(apurinic or apyrimidinic site) 5'-phosphomonoester-lyase activity" EXACT
    "DNA-(apurinic or apyrimidinic site) lyase activity" EXACT
Secondary IDs
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EC:4.2.99.18
MetaCyc:4.2.99.18-RXN
RHEA:66592
Wikipedia:AP_endonuclease