FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term ATPase-coupled intramembrane lipid carrier activity ID (Ontology) GO:0140326 (Gene Ontology)
Definition Catalysis of the movement of lipids from one membrane leaflet to the other, driven by ATP hydrolysis. This includes flippases and floppases.[ PubMed:16828084 ]
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Genes (FBgn)GO_MOLECULAR_FUNCTION
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 ATPase-coupled intramembrane lipid carrier activity (all annotations which use CV term, excluding "NOT" statements)
     enables | ATPase-coupled intramembrane lipid carrier activity       --
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molecular_function
 |__ATP-dependent activity________________
transporter activity                      |
 |__intramembrane lipid carrier activity__|
lipid carrier activity                    |
 |__intramembrane lipid carrier activity__|
                                          ATPase-coupled intramembrane lipid carrier activity  9 rec.
                                           |__flippase activity 3 rec.
                                           |   |__aminophospholipid flippase activity(+)
                                           |   |__glycerophospholipid flippase activity(+)
                                           |   |__glycosylceramide flippase activity
                                           |   |__N-retinylidene-phosphatidylethanolamine flippase activity
                                           |__floppase activity 1 rec.
                                               |__glycolipid floppase activity 1 rec.
                                               |__lipid III floppase activity
                                               |__lipopolysaccharide floppase activity
                                               |__phosphatidylcholine floppase activity
                                               |__phosphatidylethanolamine floppase activity
                                               |__phosphatidylserine floppase activity
                                               |__sphingolipid floppase activity(+)
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Is a intramembrane lipid carrier activity
ATP-dependent activity
Part of
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Synonyms
  • "aminophospholipid-transporting ATPase" RELATED
    "ATPase-coupled intramembrane lipid transporter activity" BROAD
    "ATPase-coupled phospholipid transporter activity" RELATED
    "ATPase-dependent phospholipid transporter activity" RELATED
    "phospholipid flippase activity" NARROW
    "phospholipid translocating ATPase activity" RELATED
    "phospholipid-translocating ATPase activity" RELATED
    "phospholipid-transporting ATPase activity" RELATED[ EC:7 ]
Secondary IDs
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EC:7.6.2.1
MetaCyc:3.6.3.1-RXN
Reactome:R-HSA-939763 "P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane"
Reactome:R-HSA-947591 "P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane"