FB2026_03 , released September 17, 2026

CV Term Report

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General Information

Term

P-type transmembrane transporter activity

ID (Ontology)

GO:0140358 (Gene Ontology)

Definition

Primary active transporter that auto-phosphorylates (hence P) at a key conserved aspartate residue, generating a conformational change that allows transport of the substrate. Hydrolysis of the phosphorylated Asp residue, catalyzed by the actuator (A) domain, results in another state with occluded substrates. Upon dissociation of Mg2+ and Pi, the enzyme reverts to the initial state, in which the counter-transported substrate is released into the cytosol.[ PubMed:18075584 PubMed:25918123 ]

Also Known As

"E1-E2 ATPase" ; "P-type ATPase"

Comment

Links to External Ontologies

QuickGO data AmiGO data

Annotations

Records annotated with this term OR any of its CHILD TERMS

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Results list data from multiple species. Choose a record type above to open its HitList.

Direct annotations: records annotated with this exact term (child terms are NOT included)

Data Class	Field	Direct annotations
Genes (FBgn)	GO_MOLECULAR_FUNCTION

Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records

Full annotation statements	Relevant FlyBase reports
Full annotation statements	Gene Groups	Genes
P-type transmembrane transporter activity (all annotations which use CV term, excluding "NOT" statements)
enables \| P-type transmembrane transporter activity	--

Spanning Tree (Parents/Children)

primary active transmembrane transporter activity__
ATP-dependent activity_____________________________|
                                                   ATPase-coupled transmembrane transporter activity
                                                    |__P-type transmembrane transporter activity  18 rec.
                                                        |__P-type ion transporter activity 15 rec.
                                                            |__P-type cadmium transporter activity
                                                            |__P-type calcium transporter activity(+) 5 rec.
                                                            |__P-type cobalt transporter activity
                                                            |__P-type divalent copper transporter activity
                                                            |__P-type magnesium transporter activity 2 rec.
                                                            |__P-type manganese transporter activity 1 rec.
                                                            |__P-type monovalent copper transporter activity 2 rec.
                                                            |__P-type potassium transmembrane transporter activity(+) 4 rec.
                                                            |__P-type proton-exporting transporter activity(+)
                                                            |__P-type silver transporter activity
                                                            |__P-type sodium transporter activity(+) 4 rec.
                                                            |__P-type zinc transporter activity

Spanning Tree View Settings
Parents/Children View Depth	Show hierarchy levels: for parents, for children
Relationships
Is a	ATPase-coupled transmembrane transporter activity
Part of
Synonyms & Secondary IDs
Synonyms
	"E1-E2 ATPase" EXACT "P-type ATPase" EXACT
Secondary IDs

External Crossreferences & Linkouts
	TC:3.A.3 Wikipedia:P-type_ATPase