FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
CV Term Report
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General Information
Term P-type transmembrane transporter activity ID (Ontology) GO:0140358 (Gene Ontology)
Definition Primary active transporter that auto-phosphorylates (hence P) at a key conserved aspartate residue, generating a conformational change that allows transport of the substrate. Hydrolysis of the phosphorylated Asp residue, catalyzed by the actuator (A) domain, results in another state with occluded substrates. Upon dissociation of Mg2+ and Pi, the enzyme reverts to the initial state, in which the counter-transported substrate is released into the cytosol.[ PubMed:18075584 PubMed:25918123 ]
Also Known As "E1-E2 ATPase" ; "P-type ATPase"
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Annotations
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Data Class Field Records
Genes (FBgn)  GO_MOLECULAR_FUNCTION       2
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 Full annotation statements 
Relevant FlyBase reports
 Gene Groups Genes
 P-type transmembrane transporter activity (all annotations which use CV term, excluding "NOT" statements)       2      2
     enables | P-type transmembrane transporter activity       --       2
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primary active transmembrane transporter activity__
ATP-dependent activity_____________________________|
                                                   ATPase-coupled transmembrane transporter activity
                                                    |__P-type transmembrane transporter activity  18 rec.
                                                        |__P-type ion transporter activity 16 rec.
                                                            |__P-type cadmium transporter activity
                                                            |__P-type calcium transporter activity(+) 5 rec.
                                                            |__P-type cobalt transporter activity
                                                            |__P-type divalent copper transporter activity 1 rec.
                                                            |__P-type magnesium transporter activity 2 rec.
                                                            |__P-type manganese transporter activity 1 rec.
                                                            |__P-type monovalent copper transporter activity 1 rec.
                                                            |__P-type potassium transmembrane transporter activity(+) 4 rec.
                                                            |__P-type proton-exporting transporter activity(+)
                                                            |__P-type silver transporter activity
                                                            |__P-type sodium transporter activity(+) 4 rec.
                                                            |__P-type zinc transporter activity
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Is a ATPase-coupled transmembrane transporter activity
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Synonyms
  • "E1-E2 ATPase" EXACT
    "P-type ATPase" EXACT
Secondary IDs
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TC:3.A.3
Wikipedia:P-type_ATPase